A short diversion to the Guild Wheel route on the west side of Preston will be in place from Monday 6 January.
This change will keep the popular cycling and walking route open during construction of the new Preston Western Distributor road scheme and allow people to continue to enjoy it safely.
It will affect people on the Guild Wheel between Savick Brook and the bridge over Blackpool Road.
The Guild Wheel will continue to follow its existing route from the bridge to the rear of Old Hall Cottages, when the route will temporarily run along a newly-constructed section around the construction site. It will then join up to its existing route along Savick Brook.
Once the construction work has finished in early 2023, the Guild Wheel will return to its current route.
County Councillor Keith Iddon, Cabinet member for highways and transport, said: "We have to make sure that pedestrians and cyclists are kept safe during this work. This is a slight change, which doesn't add much to the length of people's route, with just a short diversion in place.
"There'll be signs up to tell people about the diversion. We ask people to be aware of these changes and any construction taking place."
The Preston Western Distributor is one of the major road schemes as part of the Preston, South Ribble and Lancashire City Deal.
This is an agreement between Lancashire Enterprise Partnership and Preston City Council, South Ribble Borough Council and Lancashire County Council, along with central government and Homes England.
Councillor Peter Moss, Deputy Leader and Cabinet Member for Planning and Regulation at Preston City Council, said: "This diversion is vital to ensure pedestrians and cyclists are protected during the construction of the Preston Western Distributor road scheme.
"We understand how popular the Guild Wheel route is and are grateful for your patience and understanding while these works are carried out."
The City Deal will help to create more than 20,000 new private-sector jobs and see over 17,000 new homes built across the area, along with new school places, open green spaces and new health provision to cater for the growing population.
Follow City Deal on twitter @LancsCityDeal